Cross-coupling technique cracks open alcohols for chemical synthesis

Reaction set-up

Source: © Courtesy of the MacMillan lab

A new alcohol–alcohol cross coupling reaction could become a powerful new tool for synthetic chemists

A new cross-coupling technique promises to unlock the unexplored chemical space of alcohols by expanding their use as building blocks in the synthesis of new and complex chemicals. The approach, which forms a carbon–carbon bond between two distinct alcohol units in one simple step, could also help reduce the time and resources usually required to access synthetic targets, including drug candidates.