Organic chemistry – Page 8
-
ResearchChemical chainmail constructed from interlocked coordination polymers
Simple synthesis yields an ‘infinite’ structure with applications in flexible materials
-
ResearchStreamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
-
ResearchPhotochemistry frees arene functionalisation from metals
Sulfonium salts offer new possibilities for the alkylation and cyanation of aromatic molecules
-
ResearchMolecular motor running on electricity mimics biological motors
The nanomachine is based on a [3]catenane and isn’t operated through a microscope tip, unlike others
-
ResearchMechanochemistry set to expand availability of organomanganese reagents
Ball milling method avoids problems surrounding solution-based chemistry when synthesising arylmanganese nucleophiles
-
ResearchBenchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
-
ResearchManganese complex behind method for preparing silanols that uses water as an oxidant
By using water as an oxidising agent, the reaction eliminates additional reagents and unwanted side-products
-
FeatureFashion to dye for
Can colouring clothing be environmentally sustainable? Victoria Atkinson looks at how dyes have come full circle from their natural origins
-
ResearchCoca plants’ production pathway for cocaine finally unravelled
167-year-old biosynthetic mystery may be solved
-
ResearchRadium chelator researchers working to improve targeted cancer therapies
Oak Ridge National Lab team investigate factors underpinnning Ra2+ complex stability and selectivity in attempt to expand the therapeutic utility of radium-223
-
OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
-
ResearchMystery surrounding metalation reaction’s reagent excess solved
Multiple ‘base-eating’ aggregates discovered in classic directed ortho lithiation
-
ResearchQuantum chemical analysis uncovers previously overlooked contributor to carbocation stability trend
Introducing substituents destabilises the parent substrates
-
ResearchGigantic database of building blocks will help artificial intelligence uncover new organocatalysts
Publicly available dataset containing thousands of structures could help chemists develop data-driven reaction optimisation methods for organic synthesis
-
ResearchAI beats human experts when it comes to peptide design
Algorithm throws up some counter-intuitive structures in contest
-
ResearchDual use molecular motor can drive or glow
Infrared light can flip molecular machine between rotary motion and photoluminescence
-
ResearchFully automated synthesis robot sets new record in stereospecific carbon–carbon bond formation
The robotic platform can make six carbon–carbon bonds without human guidance
-
ResearchChirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
-
ResearchControversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
-
ResearchAI discovers the best general conditions yet for cross couplings, doubling yields
Algorithm works with robotic experimenter on tricky Suzuki–Miyaura reactions