Companion compound for naloxone could boost opioid reversal effects, save lives

A new compound that binds to a part of the µ-opioid receptor (µOR) could be a useful tool in preventing deaths from opioid overdose. The molecule works in conjunction with naloxone, boosting it effectiveness seven-fold.

Naloxone is an effective treatment for opioid overdose. However, larger and repeated doses are needed in response to overdoses from more potent synthetic opioids such as fentanyl.